MOMMY-IBD

Inflammatory bowel disease (IBD), including conditions like Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal (GI) tract, and its incidence and prevalence are increasing globally. Factors such as maternal smoking, diet, antibiotics, and breastfeeding during early life can impact the risk of IBD through the microbiome. However, there is a dearth of prospective human studies investigating the relationship between maternal diet, microbiome, and IBD.

The consumption of ultra-processed foods (UPFs) and food additives has become increasingly common in modern diets. Despite preclinical evidence, no human studies have yet examined the impact of maternal intake of food additives in mothers with IBD on the microbiome of their infants.

Therefore, we conduct this multi-center cohort study. We hypothesize that maternal food additive intake impacts the maternal gut microbiome, potentially affecting the microbiome/inflammation status of their offspring up to 6–7-year-old.